Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells

In the search of small molecules that can target MDM2/p53 pathway in testicular germ cell tumors (TGCTs), we identified sempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium), an alkaloid of Gelsemium sempervirens, that has been previously proposed as an inhibitor of MDM2 that ta...

Descripción completa

Detalles Bibliográficos
Autores principales: Caggiano, Cinzia, Guida, Eugenia, Todaro, Federica, Bielli, Pamela, Mori, Mattia, Ghirga, Francesca, Quaglio, Deborah, Botta, Bruno, Moretti, Fabiola, Grimaldi, Paola, Rossi, Pellegrino, Jannini, Emmanuele A., Barchi, Marco, Dolci, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595235/
https://www.ncbi.nlm.nih.gov/pubmed/33298840
http://dx.doi.org/10.1038/s41420-020-00345-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595235/
https://www.ncbi.nlm.nih.gov/pubmed/33298840
http://dx.doi.org/10.1038/s41420-020-00345-4

Ejemplares similares