The effects of PEGylation on LNP based mRNA delivery to the eye

Gene therapy is now an effective approach to treat many forms of retinal degeneration. Delivery agents that are cell-specific, allow for multiple dosing regimens, and have low immunogenicity are needed to expand the utility of gene therapy for the retina. We generated eight novel lipid nanoparticles...

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Detalles Bibliográficos
Autores principales: Ryals, Renee C., Patel, Siddharth, Acosta, Chris, McKinney, Madison, Pennesi, Mark E., Sahay, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595320/
https://www.ncbi.nlm.nih.gov/pubmed/33119640
http://dx.doi.org/10.1371/journal.pone.0241006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595320/
https://www.ncbi.nlm.nih.gov/pubmed/33119640
http://dx.doi.org/10.1371/journal.pone.0241006

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