Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein

Drug-drug interaction was suggested to have played a role in the recent death due to cardiac arrest of a patient taking pimozide, sertraline and aripiprazole antipsychotic/antidepressant combination therapy. Here, we investigated the possible involvement of P-glycoprotein (P-gp)-mediated interaction...

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Detalles Bibliográficos
Autores principales: Morishita, Hiroki, Okawa, Kozue, Ishii, Misaki, Mizoi, Kenta, Ito, Masa-aki, Arakawa, Hiroshi, Yano, Kentaro, Ogihara, Takuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595425/
https://www.ncbi.nlm.nih.gov/pubmed/33119612
http://dx.doi.org/10.1371/journal.pone.0232438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595425/
https://www.ncbi.nlm.nih.gov/pubmed/33119612
http://dx.doi.org/10.1371/journal.pone.0232438

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