Molecular mechanism of the MORC4 ATPase activation

Human Microrchidia 4 (MORC4) is associated with acute and chronic pancreatitis, inflammatory disorders and cancer but it remains largely uncharacterized. Here, we describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation. Enzymatic and binding assa...

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Detalles Bibliográficos
Autores principales: Tencer, Adam H., Cox, Khan L., Wright, Gregory M., Zhang, Yi, Petell, Christopher J., Klein, Brianna J., Strahl, Brian D., Black, Joshua C., Poirier, Michael G., Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596504/
https://www.ncbi.nlm.nih.gov/pubmed/33122719
http://dx.doi.org/10.1038/s41467-020-19278-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596504/
https://www.ncbi.nlm.nih.gov/pubmed/33122719
http://dx.doi.org/10.1038/s41467-020-19278-8

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