A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors

The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding...

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Detalles Bibliográficos
Autores principales: Baamonde, Ana, Menéndez, Luis, González-Rodríguez, Sara, Lastra, Ana, Seitz, Viola, Stein, Christoph, Machelska, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596718/
https://www.ncbi.nlm.nih.gov/pubmed/33122720
http://dx.doi.org/10.1038/s41598-020-75509-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596718/
https://www.ncbi.nlm.nih.gov/pubmed/33122720
http://dx.doi.org/10.1038/s41598-020-75509-4

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