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Mutations make gut antibodies promiscuous

In this issue, Kabbert et al. (https://doi.org/10.1084/jem.20200275) show that intestinal antibodies from healthy subjects or patients with Crohn’s disease cross-target diverse but distinct communities of the gut microbiota through a mechanism involving somatic hypermutation but not germline-encoded...

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Detalles Bibliográficos
Autores principales: Grasset, Emilie K., Cerutti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596828/
https://www.ncbi.nlm.nih.gov/pubmed/32960963
http://dx.doi.org/10.1084/jem.20201340