GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

[Image: see text] We report the identification of three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation–mRNA display selection platform. These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound state and block Ras-Raf int...

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Detalles Bibliográficos
Autores principales: Zhang, Ziyang, Gao, Rong, Hu, Qi, Peacock, Hayden, Peacock, D. Matthew, Dai, Shizhong, Shokat, Kevan M., Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596874/
https://www.ncbi.nlm.nih.gov/pubmed/33145412
http://dx.doi.org/10.1021/acscentsci.0c00514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596874/
https://www.ncbi.nlm.nih.gov/pubmed/33145412
http://dx.doi.org/10.1021/acscentsci.0c00514

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