Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

BACKGROUND: Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functions, including adhesion-dependent degranulation, are controlled by src family k...

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Detalles Bibliográficos
Autores principales: Macfarlane, James G., Dorward, David A., Ruchaud-Sparagano, Marie-Hélène, Scott, Jonathan, Lucas, Christopher D., Rossi, Adriano G., Simpson, A. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597020/
https://www.ncbi.nlm.nih.gov/pubmed/33292269
http://dx.doi.org/10.1186/s12950-020-00261-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597020/
https://www.ncbi.nlm.nih.gov/pubmed/33292269
http://dx.doi.org/10.1186/s12950-020-00261-5

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