Differential role of segments of α-mating factor secretion signal in Pichia pastoris towards granulocyte colony-stimulating factor emerging from a wild type or codon optimized copy of the gene

BACKGROUND: The methylotrophic yeast, Pichia pastoris has been widely used for the production of human therapeutics, but production of granulocyte colony-stimulating factor (G-CSF) in this yeast is low.The work reported here aimed to improve the extracellular production of G-CSF by introducing mutat...

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Detalles Bibliográficos
Autores principales: Aggarwal, Sakshi, Mishra, Saroj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597063/
https://www.ncbi.nlm.nih.gov/pubmed/33121493
http://dx.doi.org/10.1186/s12934-020-01460-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597063/
https://www.ncbi.nlm.nih.gov/pubmed/33121493
http://dx.doi.org/10.1186/s12934-020-01460-8

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