Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo

Human DNA polymerase delta (Pol δ) forms a holoenzyme complex with the DNA sliding clamp proliferating cell nuclear antigen (PCNA) to perform its essential roles in genome replication. Here, we utilize live-cell single-molecule tracking to monitor Pol δ holoenzyme interaction with the genome in real...

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Detalles Bibliográficos
Autores principales: Drosopoulos, William C., Vierra, David A., Kenworthy, Charles A., Coleman, Robert A., Schildkraut, Carl L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597369/
https://www.ncbi.nlm.nih.gov/pubmed/32023453
http://dx.doi.org/10.1016/j.celrep.2019.12.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597369/
https://www.ncbi.nlm.nih.gov/pubmed/32023453
http://dx.doi.org/10.1016/j.celrep.2019.12.101

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