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Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo

Human DNA polymerase delta (Pol δ) forms a holoenzyme complex with the DNA sliding clamp proliferating cell nuclear antigen (PCNA) to perform its essential roles in genome replication. Here, we utilize live-cell single-molecule tracking to monitor Pol δ holoenzyme interaction with the genome in real...

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Detalles Bibliográficos
Autores principales:	Drosopoulos, William C., Vierra, David A., Kenworthy, Charles A., Coleman, Robert A., Schildkraut, Carl L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597369/ https://www.ncbi.nlm.nih.gov/pubmed/32023453 http://dx.doi.org/10.1016/j.celrep.2019.12.101

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