Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients

Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging. Physiologically-based pharmacokinetic (PBPK) mode...

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Detalles Bibliográficos
Autores principales: Kovar, Lukas, Weber, Andreas, Zemlin, Michael, Kohl, Yvonne, Bals, Robert, Meibohm, Bernd, Selzer, Dominik, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598194/
https://www.ncbi.nlm.nih.gov/pubmed/32977559
http://dx.doi.org/10.3390/pharmaceutics12100908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598194/
https://www.ncbi.nlm.nih.gov/pubmed/32977559
http://dx.doi.org/10.3390/pharmaceutics12100908

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