A Novel Co-Crystal of Bexarotene and Ligustrazine Improves Pharmacokinetics and Tissue Distribution of Bexarotene in SD Rats

Bexarotene (BEX), a specific retinoic acid X receptor (RXR) agonist granted by Food and Drug Administration (FDA) approval for the clinical treatment of T cell lymphoma, has now been found to exert pharmacological effects in the nervous system, with low bioavailability and poor cerebral distribution...

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Detalles Bibliográficos
Autores principales: Ren, Shuyue, Jiao, Lingtai, Yang, Shiying, Zhang, Li, Song, Junke, Yu, Haoying, Wang, Jingrong, Lv, Tingting, Sun, Lan, Lu, Yang, Du, Guanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598278/
https://www.ncbi.nlm.nih.gov/pubmed/32977470
http://dx.doi.org/10.3390/pharmaceutics12100906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598278/
https://www.ncbi.nlm.nih.gov/pubmed/32977470
http://dx.doi.org/10.3390/pharmaceutics12100906

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