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Mitigation of liquid–liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface
Some monoclonal antibodies undergo liquid–liquid phase separation owing to self-attractive associations involving electrostatic and other soft interactions, thereby rendering monoclonal antibodies unsuitable as therapeutics. To mitigate the phase separation, formulation optimization is often perform...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598502/ https://www.ncbi.nlm.nih.gov/pubmed/33125371 http://dx.doi.org/10.1371/journal.pone.0240673 |