Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models

This paper reviews the usefulness, current status, and potential of primary human hepatocytes (PHHs) in three-dimensional (3D) cultures, also known as spheroids, in the field of pharmacokinetics (PK). Predicting PK and toxicity means pharmaceutical research can be conducted more efficiently. Various...

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Detalles Bibliográficos
Autores principales: Mizoi, Kenta, Arakawa, Hiroshi, Yano, Kentaro, Koyama, Satoshi, Kojima, Hajime, Ogihara, Takuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598599/
https://www.ncbi.nlm.nih.gov/pubmed/32977664
http://dx.doi.org/10.3390/biomedicines8100374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598599/
https://www.ncbi.nlm.nih.gov/pubmed/32977664
http://dx.doi.org/10.3390/biomedicines8100374

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