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The synergy of damage repair and retention promotes rejuvenation and prolongs healthy lifespans in cell lineages

Damaged proteins are inherited asymmetrically during cell division in the yeast Saccharomyces cerevisiae, such that most damage is retained within the mother cell. The consequence is an ageing mother and a rejuvenated daughter cell with full replicative potential. Daughters of old and damaged mother...

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Detalles Bibliográficos
Autores principales: Schnitzer, Barbara, Borgqvist, Johannes, Cvijovic, Marija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598927/
https://www.ncbi.nlm.nih.gov/pubmed/33044956
http://dx.doi.org/10.1371/journal.pcbi.1008314