Rapid prediction of crucial hotspot interactions for icosahedral viral capsid self-assembly by energy landscape atlasing validated by mutagenesis

Icosahedral viruses are under a micrometer in diameter, their infectious genome encapsulated by a shell assembled by a multiscale process, starting from an integer multiple of 60 viral capsid or coat protein (VP) monomers. We predict and validate inter-atomic hotspot interactions between VP monomers...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Ruijin, Prabhu, Rahul, Ozkan, Aysegul, Sitharam, Meera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598928/
https://www.ncbi.nlm.nih.gov/pubmed/33079933
http://dx.doi.org/10.1371/journal.pcbi.1008357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598928/
https://www.ncbi.nlm.nih.gov/pubmed/33079933
http://dx.doi.org/10.1371/journal.pcbi.1008357

Ejemplares similares