Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

Aberrant HOXA9 expression is a hallmark of most aggressive acute leukemias, notably those with KMT2A (MLL) gene rearrangements. HOXA9 overexpression not only predicts poor diagnosis and outcome but also plays a critical role in leukemia transformation and maintenance. However, our current understand...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Zhang, Yang, Zhou, Xinyue, Wright, Shaela, Hyle, Judith, Zhao, Lianzhong, An, Jie, Zhao, Xujie, Shao, Ying, Xu, Beisi, Lee, Hyeong-Min, Chen, Taosheng, Zhou, Yang, Chen, Xiang, Lu, Rui, Li, Chunliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599066/
https://www.ncbi.nlm.nih.gov/pubmed/33001025
http://dx.doi.org/10.7554/eLife.57858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599066/
https://www.ncbi.nlm.nih.gov/pubmed/33001025
http://dx.doi.org/10.7554/eLife.57858

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