PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

The transcription factor PAX6 is involved in the development of the eye and pancreatic islets, besides being associated with sleep–wake cycles. Here, we investigated a point mutation in the RED subdomain of PAX6, previously described in a human patient, to present a comprehensive study of a homozygo...

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Detalles Bibliográficos
Autores principales: Chhabra, Nirav Florian, Amarie, Oana Veronica, Wu, Moya, Amend, Anna-Lena, Rubey, Marina, Gradinger, Daniel, Irmler, Martin, Beckers, Johannes, Rathkolb, Birgit, Wolf, Eckhard, Feuchtinger, Annette, Huypens, Peter, Teperino, Raffaele, Rozman, Jan, Przemeck, Gerhard K. H., Hrabě de Angelis, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599253/
https://www.ncbi.nlm.nih.gov/pubmed/33127955
http://dx.doi.org/10.1038/s42003-020-01337-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599253/
https://www.ncbi.nlm.nih.gov/pubmed/33127955
http://dx.doi.org/10.1038/s42003-020-01337-x

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