A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor

Chloroethylagelastatin A (CEAA) is an analogue of agelastatin A (AA), a natural alkaloid derived from a marine sponge. It is under development for therapeutic use against brain tumors as it has excellent central nervous system (CNS) penetration and pre-clinical therapeutic activity against brain tum...

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Detalles Bibliográficos
Autores principales: Caulfield, Thomas R., Hayes, Karen E., Qiu, Yushi, Coban, Mathew, Seok Oh, Joon, Lane, Amy L., Yoshimitsu, Takehiko, Hazlehurst, Lori, Copland, John A., Tun, Han W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599554/
https://www.ncbi.nlm.nih.gov/pubmed/33027969
http://dx.doi.org/10.3390/biom10101407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599554/
https://www.ncbi.nlm.nih.gov/pubmed/33027969
http://dx.doi.org/10.3390/biom10101407

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