Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na(V) Channel Inhibitor

Voltage-gated sodium (Na(V)) channel subtypes, including Na(V)1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ-conotoxins are small, potent Na(V) channel inhibitors which represent potential drug leads. Of the 22 µ-conotoxins character...

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Detalles Bibliográficos
Autores principales: McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina, Schroeder, Christina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599555/
https://www.ncbi.nlm.nih.gov/pubmed/33023152
http://dx.doi.org/10.3390/biomedicines8100391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599555/
https://www.ncbi.nlm.nih.gov/pubmed/33023152
http://dx.doi.org/10.3390/biomedicines8100391

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