Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation

We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage. Interestingly, patients harboring mutations in the gene encoding this enzyme (SGPL1) often present with neurolo...

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Detalles Bibliográficos
Autores principales: Alam, Shah, Piazzesi, Antonia, Abd El Fatah, Mariam, Raucamp, Maren, van Echten-Deckert, Gerhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599816/
https://www.ncbi.nlm.nih.gov/pubmed/32998447
http://dx.doi.org/10.3390/cells9102189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599816/
https://www.ncbi.nlm.nih.gov/pubmed/32998447
http://dx.doi.org/10.3390/cells9102189

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