Transcriptional Activation of Chac1 and Other Atf4-Target Genes Induced by Extracellular l-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells

Mouse embryonic fibroblasts lacking D-3-phosphoglycerate dehydrogenase (Phgdh), which catalyzes the first step of de novo synthesis of l-serine, are particularly sensitive to depletion of extracellular L-serine. In these cells, depletion of l-serine leads to a rapid reduction of intracellular L-seri...

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Detalles Bibliográficos
Autores principales: Hamano, Momoko, Tomonaga, Shozo, Osaki, Yusuke, Oda, Hiroaki, Kato, Hisanori, Furuya, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600170/
https://www.ncbi.nlm.nih.gov/pubmed/33023086
http://dx.doi.org/10.3390/nu12103018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600170/
https://www.ncbi.nlm.nih.gov/pubmed/33023086
http://dx.doi.org/10.3390/nu12103018

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