Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice

Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of glucose tolerance and pancreatic transdifferentia...

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Detalles Bibliográficos
Autores principales: La, Que T., Ren, Binhai, Logan, Grant J., Cunningham, Sharon C., Khandekar, Neeta, Nassif, Najah T., O’Brien, Bronwyn A., Alexander, Ian E., Simpson, Ann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600325/
https://www.ncbi.nlm.nih.gov/pubmed/33023100
http://dx.doi.org/10.3390/cells9102227

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