Parallelized Latent Dirichlet Allocation Provides a Novel Interpretability of Mutation Signatures in Cancer Genomes

Mutation signatures are defined as the distribution of specific mutations such as activity of AID/APOBEC family proteins. Previous studies have reported numerous signatures, using matrix factorization methods for mutation catalogs. Different mutation signatures are active in different tumor types; h...

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Detalles Bibliográficos
Autores principales: Matsutani, Taro, Hamada, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600398/
https://www.ncbi.nlm.nih.gov/pubmed/32992754
http://dx.doi.org/10.3390/genes11101127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600398/
https://www.ncbi.nlm.nih.gov/pubmed/32992754
http://dx.doi.org/10.3390/genes11101127

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