Cargando…

Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling

Astaxanthin (AST) is a carotenoid with therapeutic values on hyperglycemia and diabetic complications. The mechanisms of action of AST remain incompletely understood. p70 S6 kinase 1 (S6K1) is a serine/threonine kinase that phosphorylates insulin receptor substrate 1 (IRS-1)(S1101) and desensitizes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Chunmei, Ma, Bixia, Chen, Junhong, Jeong, Yoonhwa, Xu, Xiulong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600478/ https://www.ncbi.nlm.nih.gov/pubmed/32998286 http://dx.doi.org/10.3390/md18100495

Ejemplares similares

Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction
por: Yin, Yinyan, et al.
Publicado: (2021)

Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress()()
por: Doscas, Michelle E., et al.
Publicado: (2014)

Astaxanthin Provides Antioxidant Protection in LPS-Induced Dendritic Cells for Inflammatory Control
por: Yin, Yinyan, et al.
Publicado: (2021)

AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle
por: Tandelilin, Andreas AK, et al.
Publicado: (2015)

Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates
por: Sun, Jing, et al.
Publicado: (2018)

Erratum to: AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle
por: Tandelilin, Andreas A. K., et al.
Publicado: (2015)

Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation
por: Xu, Xiulong, et al.
Publicado: (2017)

Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice
por: Koehl, Muriel, et al.
Publicado: (2021)

p70 S6 kinase and actin dynamics: A perspective
por: Ip, Carman K.M., et al.
Publicado: (2012)

Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells
por: Baxi, Sangita M., et al.
Publicado: (2012)

High Dose Astaxanthin Lowers Blood Pressure and Increases Insulin Sensitivity in Rats: Are These Effects Interdependent?
por: Preuss, Harry G., et al.
Publicado: (2011)

Retraction: Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells
Publicado: (2017)

Phosphorylation of IRS1 at Serine 307 in Response to Insulin in Human Adipocytes Is Not Likely to be Catalyzed by p70 Ribosomal S6 Kinase
por: Rajan, Meenu Rohini, et al.
Publicado: (2013)

Astaxanthin Suppresses MPP(+)-Induced Oxidative Damage in PC12 Cells through a Sp1/NR1 Signaling Pathway
por: Ye, Qinyong, et al.
Publicado: (2013)

TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity
por: Wainszelbaum, Marisa J., et al.
Publicado: (2012)

p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions
por: Benardais, Karelle, et al.
Publicado: (2022)

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling
por: Levin, Susan E., et al.
Publicado: (2008)

Correction: TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity
por: Wainszelbaum, Marisa J., et al.
Publicado: (2012)

Activation of p70S6 Kinase‐1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair
por: Takeda, Katsuyuki, et al.
Publicado: (2018)

P70S6 Kinase Phosphorylation: A New Site to Assess Pharmacodynamy of Sirolimus
por: Wang, Jun-Yu, et al.
Publicado: (2015)

Astaxanthin Inhibits Interleukin-6 Expression in Cerulein/Resistin-Stimulated Pancreatic Acinar Cells
por: Kwak, Min Seung, et al.
Publicado: (2021)

Astaxanthin Modulation of Signaling Pathways That Regulate Autophagy
por: Kim, Suhn Hyung, et al.
Publicado: (2019)

Protection of Astaxanthin in Astaxanthin Nanodispersions Using Additional Antioxidants
por: Anarjan, Navideh, et al.
Publicado: (2013)

Astaxanthin Promotes Nrf2/ARE Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs
por: Chen, Qing, et al.
Publicado: (2018)

Sedum takesimense Protects PC12 Cells against Corticosterone-Induced Neurotoxicity by Inhibiting Neural Apoptosis
por: Yun, Hea-Yeon, et al.
Publicado: (2020)

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy
por: Sandilands, Emma, et al.
Publicado: (2015)

Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer
por: Segatto, Ilenia, et al.
Publicado: (2016)

The Impact of p70S6 Kinase-Dependent Phosphorylation of Gemin2 in UsnRNP Biogenesis
por: Esser, Lea Marie, et al.
Publicado: (2023)

Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats
por: Liu, Shangjing, et al.
Publicado: (2017)

Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase
por: Kim, Kidae, et al.
Publicado: (2020)

Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis
por: Ye, Qinyong, et al.
Publicado: (2012)

The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
por: Park, Sungha, et al.
Publicado: (2008)

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway
por: Jiang, Kehua, et al.
Publicado: (2018)

p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation
por: Man Ip, Carman Ka, et al.
Publicado: (2014)

TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1
por: Shin, Ju Hyun, et al.
Publicado: (2013)

The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
por: Huber, Roland G., et al.
Publicado: (2015)

Detection of Astaxanthin at Different Regions of the Brain in Rats Treated with Astaxanthin Nanoemulsion
por: Chik, Mazzura Wan, et al.
Publicado: (2022)

PF-4708671 Activates AMPK Independently of p70S6K1 Inhibition
por: Vainer, Gilad W., et al.
Publicado: (2014)

Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin
por: Wang, Xuerong, et al.
Publicado: (2017)

Targeting mTOR/p70S6K/glycolysis signaling pathway restores glucocorticoid sensitivity to 4E-BP1 null Burkitt Lymphoma
por: Gu, Ling, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_f9bd9to9gk7nj1je43bbf11fr8