Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

A physiologically based pharmacokinetic (PBPK) model of selegiline (SEL), and its metabolites, was developed in silico to evaluate the disposition differences between healthy and special populations. SEL is metabolized to methamphetamine (MAP) and desmethyl selegiline (DMS) by several CYP enzymes. C...

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Detalles Bibliográficos
Autores principales: Puttrevu, Santosh Kumar, Arora, Sumit, Polak, Sebastian, Patel, Nikunj Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600566/
https://www.ncbi.nlm.nih.gov/pubmed/33008144
http://dx.doi.org/10.3390/pharmaceutics12100942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600566/
https://www.ncbi.nlm.nih.gov/pubmed/33008144
http://dx.doi.org/10.3390/pharmaceutics12100942

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