The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions

This study was designed to develop and validate a 10 probe drug cocktail named “Dual Cocktail”, composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac (Cyp2c11 in rat and CYP2C9 in human, 2 mg/kg), omeprazole (Cyp2c11 in rat and CYP2C19 in human, 2 mg/kg), dextromethorphan (Cy...

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Detalles Bibliográficos
Autores principales: Kwon, Mihwa, Jeon, Ji-Hyeon, Choi, Min-Koo, Song, Im-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600799/
https://www.ncbi.nlm.nih.gov/pubmed/33007943
http://dx.doi.org/10.3390/pharmaceutics12100938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600799/
https://www.ncbi.nlm.nih.gov/pubmed/33007943
http://dx.doi.org/10.3390/pharmaceutics12100938

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