(2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia

SIMPLE SUMMARY: Acute myeloid leukemia (AML) is one of several cancers where cancer proliferation occurs under the influence of an aberrant metabolite known as an oncometabolite produced by a mutated enzyme in the cancer cell. In AML, mutant isocitrate dehydrogenases produce the oncometabolite 2-hyd...

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Detalles Bibliográficos
Autores principales: Idle, Jeffrey R., Seipel, Katja, Bacher, Ulrike, Pabst, Thomas, Beyoğlu, Diren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600928/
https://www.ncbi.nlm.nih.gov/pubmed/33019704
http://dx.doi.org/10.3390/cancers12102842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600928/
https://www.ncbi.nlm.nih.gov/pubmed/33019704
http://dx.doi.org/10.3390/cancers12102842

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