Mutually Isomeric 2- and 4-(3-Nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens

Starting from the structure of antimycobacterial screening hit OTB-021 which was devoid of activity against ESKAPE pathogens, we designed, synthesized and tested two mutually isomeric series of novel simplified analogs, 2- and 4-(3-nitro-1,2,4-triazol-1-yl)pyrimidines, bearing various amino side cha...

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Detalles Bibliográficos
Autores principales: Chuprun, Sergey, Dar’in, Dmitry, Rogacheva, Elizaveta, Kraeva, Liudmila, Levin, Oleg, Manicheva, Olga, Dogonadze, Marine, Vinogradova, Tatiana, Bakulina, Olga, Krasavin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601023/
https://www.ncbi.nlm.nih.gov/pubmed/33019787
http://dx.doi.org/10.3390/antibiotics9100666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601023/
https://www.ncbi.nlm.nih.gov/pubmed/33019787
http://dx.doi.org/10.3390/antibiotics9100666

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