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FUT2 Secretor Status Influences Susceptibility to VP4 Strain-Specific Rotavirus Infections in South African Children

Gastroenteritis is a preventable cause of morbidity and mortality worldwide. Rotavirus vaccination has significantly reduced the disease burden, but the sub-optimal vaccine efficacy observed in low-income regions needs improvement. Rotavirus VP4 ‘spike’ proteins interact with FUT2-defined, human his...

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Detalles Bibliográficos
Autores principales: MacDonald, Jaime, Groome, Michelle J., Mans, Janet, Page, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601103/
https://www.ncbi.nlm.nih.gov/pubmed/32992488
http://dx.doi.org/10.3390/pathogens9100795