Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

Canine and human osteosarcomas (OSA) share similarities. Novel therapies are necessary for these tumours. The Bacillus anthracis toxin was reengineered to target and kill cells with high expressions of matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA). Since canine OSA expre...

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Detalles Bibliográficos
Autores principales: Mackowiak da Fonseca, Jonathan, Mackowiak da Fonseca, Ivone Izabel, Nagamine, Marcia Kazumi, Massoco, Cristina de Oliveira, Nishiya, Adriana Tomoko, Ward, Jerrold Michael, Liu, Shihui, Leppla, Stephen Howard, Bugge, Thomas Henrik, Dagli, Maria Lucia Zaidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601267/
https://www.ncbi.nlm.nih.gov/pubmed/32987941
http://dx.doi.org/10.3390/toxins12100614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601267/
https://www.ncbi.nlm.nih.gov/pubmed/32987941
http://dx.doi.org/10.3390/toxins12100614

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