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Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial

Health-promoting effects of plant foods have been emphasized in the last few decades and ascribed to the bioactive phytochemicals present therein—in particular, phenylpropanoids. The latter have been investigated for a number of preclinical biological activities, including their antioxidant power. D...

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Autores principales: Vitalini, Sara, Sardella, Andrea, Fracassetti, Daniela, Secli, Rita, Tirelli, Antonio, Lodi, Giovanni, Carrassi, Antonio, Varoni, Elena Maria, Iriti, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601283/
https://www.ncbi.nlm.nih.gov/pubmed/33027942
http://dx.doi.org/10.3390/jcm9103209
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author Vitalini, Sara
Sardella, Andrea
Fracassetti, Daniela
Secli, Rita
Tirelli, Antonio
Lodi, Giovanni
Carrassi, Antonio
Varoni, Elena Maria
Iriti, Marcello
author_facet Vitalini, Sara
Sardella, Andrea
Fracassetti, Daniela
Secli, Rita
Tirelli, Antonio
Lodi, Giovanni
Carrassi, Antonio
Varoni, Elena Maria
Iriti, Marcello
author_sort Vitalini, Sara
collection PubMed
description Health-promoting effects of plant foods have been emphasized in the last few decades and ascribed to the bioactive phytochemicals present therein—in particular, phenylpropanoids. The latter have been investigated for a number of preclinical biological activities, including their antioxidant power. Due to the paucity of human studies, in this randomized intervention trial, we investigated whether the acute intake of pigmented rice could increase the plasma bioactive levels and antiradical power in twenty healthy subjects. A crossover randomized controlled clinical trial was conducted on 19 volunteers. Artemide and Venere black rice cultivars were tested, while brown rice Carnaroli was used as a control. Each patient received randomly one serving (100 g) of rice on three different experimental days, separated by a 7-day washout period. After baseline blood withdrawal, time-course changes of plasma polyphenols, flavonoids and radical-scavenging capacity were determined at 30, 60, 120 and 180 min post rice intake. Compared to Carnaroli rice, the two black rice cultivars significantly increased the plasma levels of polyphenols and flavonoids at 60 and 120 min and, correspondingly, the plasma antiradical power at 60 min after consumption. Pigmented rice consumption can contribute to diet-related health benefits in humans.
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spelling pubmed-76012832020-11-01 Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial Vitalini, Sara Sardella, Andrea Fracassetti, Daniela Secli, Rita Tirelli, Antonio Lodi, Giovanni Carrassi, Antonio Varoni, Elena Maria Iriti, Marcello J Clin Med Article Health-promoting effects of plant foods have been emphasized in the last few decades and ascribed to the bioactive phytochemicals present therein—in particular, phenylpropanoids. The latter have been investigated for a number of preclinical biological activities, including their antioxidant power. Due to the paucity of human studies, in this randomized intervention trial, we investigated whether the acute intake of pigmented rice could increase the plasma bioactive levels and antiradical power in twenty healthy subjects. A crossover randomized controlled clinical trial was conducted on 19 volunteers. Artemide and Venere black rice cultivars were tested, while brown rice Carnaroli was used as a control. Each patient received randomly one serving (100 g) of rice on three different experimental days, separated by a 7-day washout period. After baseline blood withdrawal, time-course changes of plasma polyphenols, flavonoids and radical-scavenging capacity were determined at 30, 60, 120 and 180 min post rice intake. Compared to Carnaroli rice, the two black rice cultivars significantly increased the plasma levels of polyphenols and flavonoids at 60 and 120 min and, correspondingly, the plasma antiradical power at 60 min after consumption. Pigmented rice consumption can contribute to diet-related health benefits in humans. MDPI 2020-10-05 /pmc/articles/PMC7601283/ /pubmed/33027942 http://dx.doi.org/10.3390/jcm9103209 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vitalini, Sara
Sardella, Andrea
Fracassetti, Daniela
Secli, Rita
Tirelli, Antonio
Lodi, Giovanni
Carrassi, Antonio
Varoni, Elena Maria
Iriti, Marcello
Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
title Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
title_full Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
title_fullStr Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
title_full_unstemmed Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
title_short Polyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
title_sort polyphenol bioavailability and plasma antiradical capacity in healthy subjects after acute intake of pigmented rice: a crossover randomized controlled clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601283/
https://www.ncbi.nlm.nih.gov/pubmed/33027942
http://dx.doi.org/10.3390/jcm9103209
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