Cargando…

UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression

Oocyte maturation is a prerequisite for successful fertilization and embryo development. Incomplete oocyte maturation can result in infertility. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) has been found to be implicated in oocyte maturation and embryo development. However, the cellular and mol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Pan, Zhou, Li, Zhang, Xiaona, Yao, Lan, Ning, Jun, Han, Xiao, Ming, Caifeng, Zhao, Yunhe, Zhang, Liqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cell Death & Injury
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601359/ https://www.ncbi.nlm.nih.gov/pubmed/33030206 http://dx.doi.org/10.1042/BSR20201308

Ejemplares similares

Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells
por: Kobayashi, Eiji, et al.
Publicado: (2019)

Inhibition of UCHL1 by LDN-57444 attenuates Ang II–Induced atrial fibrillation in mice
por: Bi, Hai-Lian, et al.
Publicado: (2019)

Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model
por: Wu, Que, et al.
Publicado: (2023)

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis
por: Hu, Ning, et al.
Publicado: (2022)

CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis
por: Zhang, Qingpu, et al.
Publicado: (2020)

Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury
por: Chen, Xiaorui, et al.
Publicado: (2023)

A paradox: Fe(2+)-containing agents decreased ROS and apoptosis induced by CoNPs in vascular endothelial cells by inhibiting HIF-1α
por: Zhu, Wenfeng, et al.
Publicado: (2021)

Circ_0061012 contributes to IL-22-induced proliferation, migration and invasion in keratinocytes through miR-194-5p/GAB1 axis in psoriasis
por: He, Qi, et al.
Publicado: (2021)

2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways
por: Luo, Mengxin, et al.
Publicado: (2021)

Prostaglandin E1 protects cardiomyocytes against hypoxia-reperfusion induced injury via the miR-21-5p/FASLG axis
por: Tang, Mingxiang, et al.
Publicado: (2019)

Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2
por: AL-Megrin, Wafa A., et al.
Publicado: (2020)

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase
por: Pierotti, Catia L., et al.
Publicado: (2023)

MiR-760 enhances sensitivity of pancreatic cancer cells to gemcitabine through modulating Integrin β1
por: Yang, Dejun, et al.
Publicado: (2019)

Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production
por: Xue, Ming, et al.
Publicado: (2019)

Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors
por: Li, Jiahui, et al.
Publicado: (2019)

Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1
por: Li, Wenyuan, et al.
Publicado: (2020)

CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis
por: Lv, Chunyang, et al.
Publicado: (2020)

Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a
por: Cao, Guijun, et al.
Publicado: (2020)

The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy
por: Yiu, Wai Han, et al.
Publicado: (2023)

Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion
por: Chen, Feng, et al.
Publicado: (2023)

Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway
por: Ma, Zhenling, et al.
Publicado: (2021)

TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis
por: Lu, Hong, et al.
Publicado: (2022)

Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD(+)-Sirt3 pathway
por: Wang, Tao, et al.
Publicado: (2022)

Matrine regulates H(2)O(2)-induced oxidative stress through long non-coding RNA HOTAIR/miR-106b-5p axis via AKT and STAT3 pathways
por: Xu, Guanxue, et al.
Publicado: (2020)

The effects of myeloablative or non-myeloablative total body irradiations on intestinal tract in mice
por: Zhu, Shengyun, et al.
Publicado: (2021)

Attenuating ischemia/reperfusion injury in rat cardiac transplantation by intracoronary infusion with siRNA cocktail solution
por: Yang, Bo, et al.
Publicado: (2020)

Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats
por: Wang, Yefang, et al.
Publicado: (2020)

Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide
por: Badawy, Abdulla A.-B.
Publicado: (2020)

Knockdown of TRIM52 alleviates LPS-induced inflammatory injury in human periodontal ligament cells through the TLR4/NF-κB pathway
por: Liu, Peng, et al.
Publicado: (2020)

Evaluation of epithelial progenitor cells and growth factors in a preclinical model of wound healing induced by mesenchymal stromal cells
por: Ramos-Gonzalez, Giselle, et al.
Publicado: (2020)

Myrrh induces the apoptosis and inhibits the proliferation and migration of gastric cancer cells through down-regulating cyclooxygenase-2 expression
por: Sun, Mengxue, et al.
Publicado: (2020)

The effect of copy number on α-synuclein’s toxicity and its protective role in Bax-induced apoptosis, in yeast
por: Akintade, Damilare D., et al.
Publicado: (2020)

The roles of long noncoding RNAs in myocardial pathophysiology
por: Chen, Cheng, et al.
Publicado: (2019)

miR-206 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targetting glutaminase
por: Chen, Ying, et al.
Publicado: (2019)

Couplet medicines of leech and centipede granules improve erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats
por: Ma, Jian Xiong, et al.
Publicado: (2020)

Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway
por: Li, Junzhi, et al.
Publicado: (2020)

The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells
por: Alshangiti, Amnah M., et al.
Publicado: (2019)

Heat stress modulates differential response in skin fibroblast cells of native cattle (Bos indicus) and riverine buffaloes (Bubalus bubalis)
por: Shandilya, Umesh K., et al.
Publicado: (2020)

BTXA regulates the epithelial–mesenchymal transition and autophagy of keloid fibroblasts via modulating miR-1587/miR-2392 targeted ZEB2
por: Hou, Zhanying, et al.
Publicado: (2019)

Per2 attenuates LPS-induced chondrocyte injury through the PTEN/PI3K/Akt signalling pathway
por: Zhao, Yu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p7emhl0man2vvi3im62jqe43lf