Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies

BACE1 is the rate-limiting enzyme involved in the production and deposition of β-amyloid (Aβ). Since neurotoxic Aβ plays a critical role in Alzheimer’s disease (AD) pathogenesis, BACE1 has emerged as a key target for preventing AD. In the present study, the potential of sulforaphane, an isothiocyana...

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Detalles Bibliográficos
Autores principales: Youn, Kumju, Yoon, Jeong-Hyun, Lee, Nayoung, Lim, Gyutae, Lee, Jinhyuk, Sang, Shengmin, Ho, Chi-Tang, Jun, Mira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601397/
https://www.ncbi.nlm.nih.gov/pubmed/33023225
http://dx.doi.org/10.3390/nu12103026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601397/
https://www.ncbi.nlm.nih.gov/pubmed/33023225
http://dx.doi.org/10.3390/nu12103026

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