In Situ Gel Incorporating Disulfiram Nanoparticles Rescues the Retinal Dysfunction via ATP Collapse in Otsuka Long–Evans Tokushima Fatty Rats

We attempted to design an ophthalmic in situ gel formulation incorporating disulfiram (DIS) nanoparticles (Dis-NPs/ISG) and demonstrated the therapeutic effect of Dis-NPs/ISG on retinal dysfunction in 15-month-old Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a rat model of diabetes. The DIS parti...

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Detalles Bibliográficos
Autores principales: Deguchi, Saori, Ogata, Fumihiko, Yamaguchi, Mizuki, Minami, Misa, Otake, Hiroko, Kanai, Kazutaka, Kawasaki, Naohito, Nagai, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601925/
https://www.ncbi.nlm.nih.gov/pubmed/32993012
http://dx.doi.org/10.3390/cells9102171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601925/
https://www.ncbi.nlm.nih.gov/pubmed/32993012
http://dx.doi.org/10.3390/cells9102171

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