Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6/2 Mouse Model of Huntington’s Disease

Pyroptosis is a type of cell death that is caspase-1 (Casp-1) dependent, which leads to a rapid cell lysis, and it is linked to the inflammasome. We recently showed that pyroptotic cell death occurs in Huntington’s disease (HD). Moreover, we previously described the beneficial effects of a PARP-1 in...

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Detalles Bibliográficos
Autores principales: Paldino, Emanuela, D’Angelo, Vincenza, Laurenti, Daunia, Angeloni, Cecilia, Sancesario, Giuseppe, Fusco, Francesca R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602058/
https://www.ncbi.nlm.nih.gov/pubmed/33066292
http://dx.doi.org/10.3390/cells9102286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602058/
https://www.ncbi.nlm.nih.gov/pubmed/33066292
http://dx.doi.org/10.3390/cells9102286

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