Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1

Targeting endothelial cell (EC) metabolism should impair angiogenesis, regardless of how many angiogenic signals are present. The dependency of proliferating ECs on glucose and glutamine for energy and biomass production opens new opportunities for anti-angiogenic therapy in cancer. The aim of the p...

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Detalles Bibliográficos
Autores principales: Schoonjans, Céline A., Mathieu, Barbara, Joudiou, Nicolas, Zampieri, Luca X., Brusa, Davide, Sonveaux, Pierre, Feron, Olivier, Gallez, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602423/
https://www.ncbi.nlm.nih.gov/pubmed/33076309
http://dx.doi.org/10.3390/jcm9103308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602423/
https://www.ncbi.nlm.nih.gov/pubmed/33076309
http://dx.doi.org/10.3390/jcm9103308

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