Cargando…

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1

Targeting endothelial cell (EC) metabolism should impair angiogenesis, regardless of how many angiogenic signals are present. The dependency of proliferating ECs on glucose and glutamine for energy and biomass production opens new opportunities for anti-angiogenic therapy in cancer. The aim of the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schoonjans, Céline A., Mathieu, Barbara, Joudiou, Nicolas, Zampieri, Luca X., Brusa, Davide, Sonveaux, Pierre, Feron, Olivier, Gallez, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602423/ https://www.ncbi.nlm.nih.gov/pubmed/33076309 http://dx.doi.org/10.3390/jcm9103308

Ejemplares similares

Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI
por: Buyse, Chloé, et al.
Publicado: (2021)

Metabolic imaging using hyperpolarized (13)C‐pyruvate to assess sensitivity to the B‐Raf inhibitor vemurafenib in melanoma cells and xenografts
por: Acciardo, Stefania, et al.
Publicado: (2019)

Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies
por: Danhier, Pierre, et al.
Publicado: (2017)

Influence of Cell Detachment on the Respiration Rate of Tumor and Endothelial Cells
por: Danhier, Pierre, et al.
Publicado: (2013)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer
por: Kitayama, Kishu, et al.
Publicado: (2017)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
por: Thabault, Léopold, et al.
Publicado: (2021)

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities
por: Tiersma, Jiske F., et al.
Publicado: (2022)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Pyruvate dehydrogenase levels are low in sepsis
por: Nuzzo, E, et al.
Publicado: (2015)

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
por: Sutendra, Gopinath, et al.
Publicado: (2013)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2018)

Assessment of Hyperosmolar Blood–Brain Barrier Opening in Glioblastoma via Histology with Evans Blue and DCE-MRI
por: Conq, Jérôme, et al.
Publicado: (2023)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
por: Jha, Mithilesh Kumar, et al.
Publicado: (2013)

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
por: Zhou, Xiaoli, et al.
Publicado: (2016)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
por: Leem, Jaechan, et al.
Publicado: (2016)

Global view of cognate kinase activation by the human pyruvate dehydrogenase complex
por: Guevara, Elena L., et al.
Publicado: (2017)

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases
por: Jane, Esther P., et al.
Publicado: (2021)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer
por: Mizuno, Yuta, et al.
Publicado: (2020)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
por: Singleton, Dean C., et al.
Publicado: (2020)

Pyruvate Dehydrogenase Kinase 4: Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue
por: Cadoudal, Thomas, et al.
Publicado: (2008)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
por: Honda, Kazuhisa, et al.
Publicado: (2017)

Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages
por: Na, Yi Rang, et al.
Publicado: (2020)

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma
por: Kuo, Yu-Hsuan, et al.
Publicado: (2021)

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
por: Forteza, Maria J, et al.
Publicado: (2023)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models
por: Neveu, Marie-Aline, et al.
Publicado: (2016)

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
por: Sonveaux, Pierre, et al.
Publicado: (2012)

Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification
por: Buyse, Chloe, et al.
Publicado: (2022)

Mismatch between Bioluminescence Imaging (BLI) and MRI When Evaluating Glioblastoma Growth: Lessons from a Study Where BLI Suggested “Regression” while MRI Showed “Progression”
por: Bausart, Mathilde, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ggshgms8li64n1qvdvcbsglm0f