Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

SIMPLE SUMMARY: Drugs that sensitise tumours to chemotherapy by enhancing cell death signalling are of significant clinical interest. However, it is challenging to determine which colorectal cancer patients may benefit from such sensitisers. The ability to predict this would be advantageous. Here we...

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Detalles Bibliográficos
Autores principales: O’Farrell, Alice C., Jarzabek, Monika A., Lindner, Andreas U., Carberry, Steven, Conroy, Emer, Miller, Ian S., Connor, Kate, Shiels, Liam, Zanella, Eugenia R., Lucantoni, Federico, Lafferty, Adam, White, Kieron, Meyer Villamandos, Mariangela, Dicker, Patrick, Gallagher, William M., Keek, Simon A., Sanduleanu, Sebastian, Lambin, Philippe, Woodruff, Henry C., Bertotti, Andrea, Trusolino, Livio, Byrne, Annette T., Prehn, Jochen H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602510/
https://www.ncbi.nlm.nih.gov/pubmed/33066609
http://dx.doi.org/10.3390/cancers12102978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602510/
https://www.ncbi.nlm.nih.gov/pubmed/33066609
http://dx.doi.org/10.3390/cancers12102978

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