The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy

The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR), and a ligand-binding domain (LBD) that binds androgens, including testosterone (T) and dihydrotestosterone (DHT). Ligand...

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Detalles Bibliográficos
Autores principales: Messner, Elisabeth A., Steele, Thomas M., Tsamouri, Maria Malvina, Hejazi, Nazila, Gao, Allen C., Mudryj, Maria, Ghosh, Paramita M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602609/
https://www.ncbi.nlm.nih.gov/pubmed/33076388
http://dx.doi.org/10.3390/biomedicines8100422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602609/
https://www.ncbi.nlm.nih.gov/pubmed/33076388
http://dx.doi.org/10.3390/biomedicines8100422

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