Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice

MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based p...

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Detalles Bibliográficos
Autores principales: Reig-López, Javier, Maldonado, María del Mar, Merino-Sanjuan, Matilde, Cruz-Collazo, Ailed M., Ruiz-Calderón, Jean F., Mangas-Sanjuán, Victor, Dharmawardhane, Suranganie, Duconge, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602742/
https://www.ncbi.nlm.nih.gov/pubmed/33076517
http://dx.doi.org/10.3390/pharmaceutics12100975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602742/
https://www.ncbi.nlm.nih.gov/pubmed/33076517
http://dx.doi.org/10.3390/pharmaceutics12100975

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