FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity

The resurrection of pseudogenes during evolution produced lncRNAs with new biological function. Here we show that pseudogene-evolution created an Oct4 pseudogene lncRNA that is able to direct epigenetic silencing of the parental Oct4 gene via a 2-step, lncRNA dependent mechanism. The murine Oct4 pse...

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Detalles Bibliográficos
Autores principales: Scarola, Michele, Comisso, Elisa, Rosso, Massimo, Del Sal, Giannino, Schneider, Claudio, Schoeftner, Stefan, Benetti, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603346/
https://www.ncbi.nlm.nih.gov/pubmed/33128015
http://dx.doi.org/10.1038/s42003-020-01355-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603346/
https://www.ncbi.nlm.nih.gov/pubmed/33128015
http://dx.doi.org/10.1038/s42003-020-01355-9

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