Cargando…

Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice

SIMPLE SUMMARY: The presence and the role of TUFT cells in pancreatic ductal adenocarcinoma (PDAC) is discussed. Therefore, we decided to inactivate the POU2F3 gene, which is essential for TUFT cells development, in an aggressive PDAC mice model known as PDX1-Cre;LSL-Kras(G12D);Ink4a(fl/fl). Morphol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bintz, Jennifer, Abuelafia, Analía Meilerman, Gerbe, François, Baudoin, Elodie, Auphan-Anezin, Nathalie, Sidot, Emmanuelle, Jay, Philippe, Iovanna, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603360/ https://www.ncbi.nlm.nih.gov/pubmed/33086657 http://dx.doi.org/10.3390/biology9100341

Ejemplares similares

Limitation and challenges in using pancreatic cancer‐derived organoids as a preclinical tool
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2022)

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity
por: Fraunhoffer, Nicolas Alejandro, et al.
Publicado: (2022)

Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2022)

Identification of germ cell-specific VASA and IFITM3 proteins in human ovarian endometriosis
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2015)

Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy
por: Verdeil, Grégory, et al.
Publicado: (2019)

Specific targeting of CD163(+) TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression
por: Etzerodt, Anders, et al.
Publicado: (2019)

Disrupted Lymph Node and Splenic Stroma in Mice with Induced Inflammatory Melanomas Is Associated with Impaired Recruitment of T and Dendritic Cells
por: Soudja, Saïdi M., et al.
Publicado: (2011)

Long-term apoptosis-related protein expression in the diabetic mouse ovary
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2018)

Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2023)

Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma
por: Huang, Can, et al.
Publicado: (2019)

On the origin of POU5F1
por: Frankenberg, Stephen, et al.
Publicado: (2013)

POU2F2-oriented network promotes human gastric cancer metastasis
por: Wang, Si-Meng, et al.
Publicado: (2016)

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis
por: Simó-Riudalbas, Laia, et al.
Publicado: (2022)

Pou4f1 and Pou4f2 Are Dispensable for the Long-Term Survival of Adult Retinal Ganglion Cells in Mice
por: Huang, Liang, et al.
Publicado: (2014)

SOX12 Promotes Thyroid Cancer Cell Proliferation and Invasion by Regulating the Expression of POU2F1 and POU3F1
por: Su, Zhenxi, et al.
Publicado: (2022)

The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress
por: Fionda, Cinzia, et al.
Publicado: (2019)

Functional Analysis of Sheep POU2F3 Isoforms
por: Ma, Guang-Wei, et al.
Publicado: (2019)

IFNγ producing CD8(+) T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas
por: Buferne, Michel, et al.
Publicado: (2015)

Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart
por: Maskell, Lauren J, et al.
Publicado: (2017)

POU1F1/Pou1f1 c.143-83A > G Variant Disrupts the Branch Site in Pre-mRNA and Leads to Dwarfism
por: Akiba, Kazuhisa, et al.
Publicado: (2022)

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer
por: Etzerodt, Anders, et al.
Publicado: (2020)

Sequence variation in the human transcription factor gene POU5F1
por: Hussain, Shehnaz K, et al.
Publicado: (2008)

Mammalian-Specific Sequences in Pou3f2 Contribute to Maternal Behavior
por: Nasu, Makoto, et al.
Publicado: (2014)

Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1
por: Martinez-Lopez, Jesus E., et al.
Publicado: (2015)

Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation
por: Daigneault, Bradford W., et al.
Publicado: (2018)

Intronic variant in POU1F1 associated with canine pituitary dwarfism
por: Kyöstilä, Kaisa, et al.
Publicado: (2021)

Cochlear implantation in a patient with a POU4F3 mutation
por: Miyake, Keitaro, et al.
Publicado: (2020)

Recurrent Superenhancer of the Oncogene POU5F1B in Colorectal Cancers
por: Tao, Han-chuan, et al.
Publicado: (2021)

PMON145 The Role of Pou3f4 in Pituitary Development and Disease
por: Masser, Bailey, et al.
Publicado: (2022)

Molecular Cloning of Rat and Porcine Retina-derived POU Domain Factor 1 (POU6F2) from a Pituitary cDNA Library
por: YOSHIDA, Saishu, et al.
Publicado: (2014)

Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2
por: Chen, Hung Yen, et al.
Publicado: (2016)

POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity
por: Szczepanski, Aileen Patricia, et al.
Publicado: (2022)

POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis
por: Cai, Shouliang, et al.
Publicado: (2016)

The interaction between long non-coding RNA LINC01564 and POU2F1 promotes the proliferation and metastasis of gastric cancer
por: Wang, Jixu, et al.
Publicado: (2022)

Primary renal sarcoma with SS18::POU5F1 gene fusion
por: Argani, Pedram, et al.
Publicado: (2022)

RETRACTED ARTICLE: The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer
por: Xiao, Yizhi, et al.
Publicado: (2020)

Retraction Note: The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer
por: Xiao, Yizhi, et al.
Publicado: (2022)

The intestinal epithelium tuft cells: specification and function
por: Gerbe, François, et al.
Publicado: (2012)

The POU Transcription Factor POU-M2 Regulates Vitellogenin Receptor Gene Expression in the Silkworm, Bombyx mori
por: Shen, Guanwang, et al.
Publicado: (2020)

Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development
por: Onichtchouk, Daria, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_dvqpsvcjfr5cskrjis24e39t4c