α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer’s disease

BACKGROUND: The disintegrin metalloproteinase 10 (ADAM10) is the main α-secretase acting in the non-amyloidogenic processing of APP. Some ADAM10 gene variants have been associated with higher susceptibility to develop late-onset AD, though clear clinical-genetic correlates remain elusive. METHODS: C...

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Detalles Bibliográficos
Autores principales: Agüero, Pablo, Sainz, María José, García-Ayllón, María-Salud, Sáez-Valero, Javier, Téllez, Raquel, Guerrero-López, Rosa, Pérez-Pérez, Julián, Jiménez-Escrig, Adriano, Gómez-Tortosa, Estrella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603780/
https://www.ncbi.nlm.nih.gov/pubmed/33129344
http://dx.doi.org/10.1186/s13195-020-00708-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603780/
https://www.ncbi.nlm.nih.gov/pubmed/33129344
http://dx.doi.org/10.1186/s13195-020-00708-0

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