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Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study

BACKGROUND: Some observational epidemiologic studies suggest that dietary and serum carotenoids are associated with reduced cardiovascular disease mortality. METHODS: Three thousand and sixty-one subjects (1,190 males and 1,871 females), aged 39 to 80 years, were recruited from residents of Hokkaido...

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Autores principales: Ito, Yoshinori, Kurata, Mio, Suzuki, Koji, Hamajima, Nobuyuki, Hishida, Hitoshi, Aoki, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603911/
https://www.ncbi.nlm.nih.gov/pubmed/16837766
http://dx.doi.org/10.2188/jea.16.154
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author Ito, Yoshinori
Kurata, Mio
Suzuki, Koji
Hamajima, Nobuyuki
Hishida, Hitoshi
Aoki, Kunio
author_facet Ito, Yoshinori
Kurata, Mio
Suzuki, Koji
Hamajima, Nobuyuki
Hishida, Hitoshi
Aoki, Kunio
author_sort Ito, Yoshinori
collection PubMed
description BACKGROUND: Some observational epidemiologic studies suggest that dietary and serum carotenoids are associated with reduced cardiovascular disease mortality. METHODS: Three thousand and sixty-one subjects (1,190 males and 1,871 females), aged 39 to 80 years, were recruited from residents of Hokkaido, Japan who had attended comprehensive health check-up programs from 1988 through 1995. Serum levels of α-carotene, β-carotene, and lycopene were separately determined by high-performance liquid chromatography. Serum levels of total carotene consisted of the sum of α-carotene, β-carotene, and lycopene levels. Each serum level of α-carotene, β-carotene, lycopene, total carotene, triglyceride, and alanine transaminase (ALT) activity was transformed logarithmically. The hazard ratios of serum α- and β-carotenes, lycopene, and total carotene values were estimated by the Cox proportional hazard model after adjusting for sex, age, and other potential confounding factors. RESULTS: During the 11.9-year follow-up period, 80 deaths (49 males and 31 females) from cardiovascular disease, 40 deaths from heart disease, and 37 deaths from stroke were identified among the cohort subjects. High serum values of carotenoids such as α- and β-carotenes, and lycopene were found to be significantly associated with low hazard ratios for cardiovascular disease mortality. However, a significant inverse association between high serum lycopene value and the risk for stroke mortality was not always observed. CONCLUSIONS: High serum levels of total carotene, comprising α- and β-carotenes and lycopene, may reduce the risk for cardiovascular disease mortality among the Japanese population.
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spelling pubmed-76039112020-11-17 Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study Ito, Yoshinori Kurata, Mio Suzuki, Koji Hamajima, Nobuyuki Hishida, Hitoshi Aoki, Kunio J Epidemiol Original Article BACKGROUND: Some observational epidemiologic studies suggest that dietary and serum carotenoids are associated with reduced cardiovascular disease mortality. METHODS: Three thousand and sixty-one subjects (1,190 males and 1,871 females), aged 39 to 80 years, were recruited from residents of Hokkaido, Japan who had attended comprehensive health check-up programs from 1988 through 1995. Serum levels of α-carotene, β-carotene, and lycopene were separately determined by high-performance liquid chromatography. Serum levels of total carotene consisted of the sum of α-carotene, β-carotene, and lycopene levels. Each serum level of α-carotene, β-carotene, lycopene, total carotene, triglyceride, and alanine transaminase (ALT) activity was transformed logarithmically. The hazard ratios of serum α- and β-carotenes, lycopene, and total carotene values were estimated by the Cox proportional hazard model after adjusting for sex, age, and other potential confounding factors. RESULTS: During the 11.9-year follow-up period, 80 deaths (49 males and 31 females) from cardiovascular disease, 40 deaths from heart disease, and 37 deaths from stroke were identified among the cohort subjects. High serum values of carotenoids such as α- and β-carotenes, and lycopene were found to be significantly associated with low hazard ratios for cardiovascular disease mortality. However, a significant inverse association between high serum lycopene value and the risk for stroke mortality was not always observed. CONCLUSIONS: High serum levels of total carotene, comprising α- and β-carotenes and lycopene, may reduce the risk for cardiovascular disease mortality among the Japanese population. Japan Epidemiological Association 2006-07-13 /pmc/articles/PMC7603911/ /pubmed/16837766 http://dx.doi.org/10.2188/jea.16.154 Text en © 2006 Japan Epidemiological Association. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Ito, Yoshinori
Kurata, Mio
Suzuki, Koji
Hamajima, Nobuyuki
Hishida, Hitoshi
Aoki, Kunio
Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study
title Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study
title_full Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study
title_fullStr Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study
title_full_unstemmed Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study
title_short Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study
title_sort cardiovascular disease mortality and serum carotenoid levels: a japanese population-based follow-up study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603911/
https://www.ncbi.nlm.nih.gov/pubmed/16837766
http://dx.doi.org/10.2188/jea.16.154
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