K-Ras–Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated

K-RAS is frequently mutated in human lung adenocarcinomas (ADCs), and the p53 pathway plays a central role in cellular defense against oncogenic K-RAS mutation. However, in mouse lung cancer models, oncogenic K-Ras mutation alone can induce ADCs without p53 mutation, and loss of p53 does not have a...

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Detalles Bibliográficos
Autores principales: Lee, You-Soub, Lee, Ja-Yeol, Song, Soo-Hyun, Kim, Da-Mi, Lee, Jung-Won, Chi, Xin-Zi, Ito, Yoshiaki, Bae, Suk-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604022/
https://www.ncbi.nlm.nih.gov/pubmed/33115981
http://dx.doi.org/10.14348/molcells.2020.0182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604022/
https://www.ncbi.nlm.nih.gov/pubmed/33115981
http://dx.doi.org/10.14348/molcells.2020.0182

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