TGR5 deficiency aggravates hepatic ischemic/reperfusion injury via inhibiting SIRT3/FOXO3/HIF-1ɑ pathway

Ischemia/reperfusion (I/R) injury is responsible for liver injury during hepatic resection and liver transplantation. The plasma membrane-bound G protein-coupled bile acid receptor (TGR5) could regulate immune response in multiple liver diseases. Nevertheless, the underlying role of TGR5 in hepatic...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Wei, Song, Li, Lei, Qiu, Jiannan, Zhou, Shun, Shi, Chengyu, Shi, Yong, Zhou, Haoming, Lu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604280/
https://www.ncbi.nlm.nih.gov/pubmed/33298860
http://dx.doi.org/10.1038/s41420-020-00347-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604280/
https://www.ncbi.nlm.nih.gov/pubmed/33298860
http://dx.doi.org/10.1038/s41420-020-00347-2

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