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TGR5 deficiency aggravates hepatic ischemic/reperfusion injury via inhibiting SIRT3/FOXO3/HIF-1ɑ pathway
Ischemia/reperfusion (I/R) injury is responsible for liver injury during hepatic resection and liver transplantation. The plasma membrane-bound G protein-coupled bile acid receptor (TGR5) could regulate immune response in multiple liver diseases. Nevertheless, the underlying role of TGR5 in hepatic...
Autores principales: | Wang, Qi, Wei, Song, Li, Lei, Qiu, Jiannan, Zhou, Shun, Shi, Chengyu, Shi, Yong, Zhou, Haoming, Lu, Ling |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604280/ https://www.ncbi.nlm.nih.gov/pubmed/33298860 http://dx.doi.org/10.1038/s41420-020-00347-2 |
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