Structural basis for CDK7 activation by MAT1 and Cyclin H

Cyclin-dependent kinase 7 (CDK7), Cyclin H, and the RING-finger protein MAT1 form the heterotrimeric CDK-activating kinase (CAK) complex which is vital for transcription and cell-cycle control. When associated with the general transcription factor II H (TFIIH) it activates RNA polymerase II by hyper...

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Detalles Bibliográficos
Autores principales: Peissert, Stefan, Schlosser, Andreas, Kendel, Rafaela, Kuper, Jochen, Kisker, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604442/
https://www.ncbi.nlm.nih.gov/pubmed/33055219
http://dx.doi.org/10.1073/pnas.2010885117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604442/
https://www.ncbi.nlm.nih.gov/pubmed/33055219
http://dx.doi.org/10.1073/pnas.2010885117

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